Revisiting post-infectious glomerulonephritis in the emerging era of C3 glomerulopathy
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چکیده
منابع مشابه
Revisiting post-infectious glomerulonephritis in the emerging era of C3 glomerulopathy
BACKGROUND Post-infectious glomerulonephritis (PIGN) is an immune complex-mediated glomerular injury that typically resolves. Dominant C3 deposition is characteristic of PIGN, but with the emergence of C3 glomerulonephritis (C3GN) as a distinct entity, it is unclear how the pathologic similarities between PIGN and C3GN should be reconciled. Therefore, nephrologists and nephropathologists need a...
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C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases caused by abnormal control of complement activation with deposition of complement component C3 in glomeruli leading to variable glomerular inflammation. Before the recognition of the unique pathogenesis of these cases, they were variably classified according to their morphological features. C3 glomerulopa...
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C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents th...
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ژورنال
عنوان ژورنال: Clinical Kidney Journal
سال: 2016
ISSN: 2048-8505,2048-8513
DOI: 10.1093/ckj/sfw032